Impact of Rubber Stoppers on Drug Quality and Stability
Rubber stoppers, often overlooked yet crucial components in the pharmaceutical realm, exert a profound influence on the quality, efficacy, and stability of drugs. The main function of the pharmaceutical rubber stopper is to provide a good seal for the medicine contained in the bottle to prevent the medicine from being contaminated by bacteria and deterioration. Ensuring Drug Container Closure Integrity The primary role of rubber stoppers is to maintain the container closure integrity of pharmaceutical vials or bottles . By forming a hermetic seal, these stoppers prevent the ingress of air, moisture, or contaminants into the container. This barrier shields the drug formulation from external factors that could compromise its stability, potency, or sterility. Compatibility with Drug Formulations Rubber stoppers are designed to be compatible with various drug formulations, ensuring that they do not interact or adversely affect the drug product. Compatibility testing is i